The reduction of 3-methoxy-4-(phenylthio)benzoic acid methyl ester (I) with LiAlH4 in ether gives 3-methoxy-4-(phenylthio)benzyl alcohol (II), which by reaction with SOCl2 in dichloromethane yields the corresponding benzyl chloride (III). The reaction of (III) with NaCN in DMF affords 3-methoxy-4-(phenylthio)phenylacetonitrile (IV), which by reaction with ethylformate by means of sodium methoxide in benzene gives 2-formyl-2-[3-methoxy-4-(phenylthio)phenyl]acetonitrile (V). The cyclization of (V) with semicarbazide in methanol - water yields 3-amino-4-[3-methoxy-4-(phenylthio)phenyl]pyrazole-2-carboxamide (VI), which is submitted to a new cyclization process with ethyl orthoformate at 110 C, affording 8-[3-methoxy-4-(phenylthio)phenyl]pyrazolo[1,5-a]-1,3,5-triazine (VII). Finally, this compound is oxidized with sodium metaperiodate in methanol - water. When the oxidation of (VII) is performed with tert-butyl hypochlorite in l-(-)-menthol and pyridine and cooled at -25 to -30 C, the (-)-BOF-4272 isomer is obtained; with d-(+)-menthol, the (+)-BOF-4272 is also obtained.