【药物名称】LU-29-066
化学结构式(Chemical Structure):
参考文献No.539255
标题:Synthesis of [11C]LU 29-066, a 5-HT2 receptor antagonist
作者:Amokhtari, M.; et al.
来源:J Label Compd Radiopharm 1999,42(5),437
合成路线图解说明:

Piperidinoindole (I) was alkylated with chloroacetonitrile in the presence of Et3N in N-methylpyrrolidinone to afford nitrile (II), which was reduced to primary amine (III) by means of LiAlH4 and AlCl3. A further alkylation-reduction sequence over (III) provided in turn nitrile (IV) and then amine (V). Finally, condensation with phosgene yielded the target imidazolidinone (1).

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