Teriflunomide, HMR-1726, 1726, A-771726, RS-61980, SU-0020-药物合成数据库

【药物名称】Teriflunomide, HMR-1726, 1726, A-771726, RS-61980, SU-0020

化学结构式(Chemical Structure):

参考文献No.	16360
标题:	Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these cpds. and use of such drugs
作者:	Bartlett, R.R.; K鋗merer, F.-J. (Aventis SA)
来源:	EP 0527736; JP 1993506425; JP 1999322700; JP 1999343285; US 5494911; US 5532259; WO 9117748

合成路线图解说明: 5-Methylisoxazole-4-carboxylic acid (I) was converted to the corresponding acid chloride (II) upon refluxing with SOCl2. Coupling of acid chloride (II) with 4-(trifluoromethyl)aniline (III) produced anilide (IV). Finally, isoxazole ring opening in the presence of NaOH gave rise to the title cyano amide.

参考文献No.	25342
标题:	Immunosuppressive agents
作者:	Coghlan, M.J.; Luly, J.R.; Wiedeman, P.E. (Abbott Laboratories Inc.)
来源:	WO 9424095

合成路线图解说明: 5-Methylisoxazole-4-carboxylic acid (I) was converted to the corresponding acid chloride (II) upon refluxing with SOCl2. Coupling of acid chloride (II) with 4-(trifluoromethyl)aniline (III) produced anilide (IV). Finally, isoxazole ring opening in the presence of NaOH gave rise to the title cyano amide.