By esterification of the acetonide of pantothenic acid (I) with (1S,2S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]-cyclohexanol (II) by means of dimethylaminopyridine (DMAP) and tosyl chloride in ethyl acetate (1) or DMAP and dicyclohexylcarbodiimide (DCC) in refluxing toluene (2). The starting compounds (I) and (II) have been prepared as follows: 1) The cyclization of pantothenic acid calcium salt (III) with 2,2-dimethoxypropane (IV) by means of oxalic acid and p-toluenesulfonic acid in refluxing acetones gives the acetonide (I). 2) The condensation of the carbamate (V) with the secondary amine (VI) by heating at 120 C yields the urea derivative (II).

By esterification of the acetonide of pantothenic acid (I) with (1S,2S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]-cyclohexanol (II) by means of dimethylaminopyridine (DMAP) and tosyl chloride in ethyl acetate (1) or DMAP and dicyclohexylcarbodiimide (DCC) in refluxing toluene (2). The starting compounds (I) and (II) have been prepared as follows: 1) The cyclization of pantothenic acid calcium salt (III) with 2,2-dimethoxypropane (IV) by means of oxalic acid and p-toluenesulfonic acid in refluxing acetones gives the acetonide (I). 2) The condensation of the carbamate (V) with the secondary amine (VI) by heating at 120 C yields the urea derivative (II).