Amorolfine hydrochloride, MT-861, Ro-14-4767/000(free base), Ro-14-4767/002, Pekiron, Bekiron, Loceryl-药物合成数据库

【药物名称】Amorolfine hydrochloride, MT-861, Ro-14-4767/000(free base), Ro-14-4767/002, Pekiron, Bekiron, Loceryl

化学结构式(Chemical Structure):

参考文献No.	66366
标题:	RO-144,767/002
作者:	Blancafort, P.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1982,7(7),492

合成路线图解说明: By condensation of 3-(4-tert-amylphenyl)propionaldehyde (I) with 2,6-dimethylmorpholine (II) by heating at 100 C in toluene, followed by hydrogenation with H2 over Pd/C in the same solvent.

参考文献No.	701321
标题:	Piperidines morpholines, etc., and fungicidal compsns. Thereof
作者:	Pfiffner, A.; Bohnen, K. (Roche)
来源:	US 4202894; US 4241058

合成路线图解说明: By condensation of 3-(4-tert-amylphenyl)propionaldehyde (I) with 2,6-dimethylmorpholine (II) by heating at 100 C in toluene, followed by hydrogenation with H2 over Pd/C in the same solvent.