Carvotroline hydrochloride, Wy-47791-药物合成数据库

【药物名称】Carvotroline hydrochloride, Wy-47791

化学结构式(Chemical Structure):

参考文献No.	154510
标题:	WY-47,791
作者:	Abou-Gharbia, M.; Marquis, K.; Andree, T.
来源:	Drugs Fut 1991,16(11),1008

合成路线图解说明: The reaction of 4-fluorophenylhydrazine, hydrochloride (I) with 4-piperidone hydrochloride hydrate (II) in refluxing ethanol afforded 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indole (III) in 82% yield. Compound (III) was reacted with 4-vinylpyridine in THF in the presence of acetic acid to give WY-47,791 free base in 85% yield which was converted to the hydrochloride salt.

参考文献No.	154857
标题:	Antipsychotic activity of substituted gamma-carbolines
作者:	Moyer, J.A.; Andree, T.H.; Abou-Gharbia, M.; Patel, U.A.; Muth, E.A.; Webb, M.B.
来源:	J Med Chem 1987,301818-23

合成路线图解说明: The reaction of 4-fluorophenylhydrazine, hydrochloride (I) with 4-piperidone hydrochloride hydrate (II) in refluxing ethanol afforded 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indole (III) in 82% yield. Compound (III) was reacted with 4-vinylpyridine in THF in the presence of acetic acid to give WY-47,791 free base in 85% yield which was converted to the hydrochloride salt.