【药物名称】Arofylline, LAS-31025
化学结构式(Chemical Structure):
参考文献No.15471
标题:New xanthine derivs.
作者:Gristwood, R.W.; Vega Noverola, A.; Prieto Soto, J.M.; Moragues Mauri, J. (Almirall Prodesfarma, SA)
来源:EP 0435811; JP 1993500226; US 5223504; WO 9109859
合成路线图解说明:

Nitrosation of 1-(4-chlorophenyl)-3-propyl-6-aminouracil (I) by means of sodium nitrite and formic acid in hot formamide afforded the 5-nitroso derivative (II). This was reduced with sodium dithionite at 100 C to produce the intermediate diamino uracil (III) which, on further heating at 190 C in formamide, gave rise to the title xanthine.

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