【药物名称】Efaproxiral sodium, RSR-13, Revaproxyn, Efaproxyn
化学结构式(Chemical Structure):
参考文献No.65613
标题:Allosteric hemoglobin modifiers
作者:Abraham, D.J.; Mehanna, A.; Randad, R.; Mahran, M.
来源:US 5049695; WO 9112235
合成路线图解说明:

Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2, followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III). Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.

参考文献No.143376
标题:Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents
作者:Randad, R.S.; Mahran, M.A.; Mehanna, A.S.; Abraham, D.J.
来源:J Med Chem 1991,34(2),752
合成路线图解说明:

Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2, followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III). Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.

参考文献No.772524
标题:Efaproxiral Sodium
作者:McIntyre, J.; Casta馿r, J.
来源:Drugs Fut 2003,28(12),1159
合成路线图解说明:

Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2, followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III). Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.

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