EF-4040, ME-3407-药物合成数据库

【药物名称】EF-4040, ME-3407

化学结构式(Chemical Structure):

参考文献No.	13902
标题:	Azole derivs. and antiulcerative compsn. containing same
作者:	Katano, K.; Tomomoto, T.; Ogino, H.; Yamazaki, N.; Hirano, F.; Yuda, Y.; Konno, F.; Nishio, M.; Machinami, T.; Shibahara, S.; Tsuruoka, T.; Inouye, S. (Meiji Seika Kaisha, Ltd.)
来源:	EP 0405976; JP 1991218377; US 5079255; US 5141946; US 5200407

合成路线图解说明: 2-Mercaptothiazolo[5,4-b]pyridine (I) is treated with chloroacetic acid butyl ester (II) in the presence of potassium carbonate in DMF to give 2-[(butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine (III), which is oxidized with m-chloroperbenzoic acid in dichloromethane.

参考文献No.	235073
标题:	ME-3407
作者:	Casta馿r, J.; Mealy, N.; Prous, J.
来源:	Drugs Fut 1994,19(1),31

合成路线图解说明: 2-Mercaptothiazolo[5,4-b]pyridine (I) is treated with chloroacetic acid butyl ester (II) in the presence of potassium carbonate in DMF to give 2-[(butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine (III), which is oxidized with m-chloroperbenzoic acid in dichloromethane.