Zifrosilone, MDL-73745-药物合成数据库

【药物名称】Zifrosilone, MDL-73745

化学结构式(Chemical Structure):

参考文献No.	13675
标题:	Novel acetylcholinesterase inhibitors
作者:	Schirlin, D.; Collard, J.-N.; Hornsperger, J.-M. (Merrell Pharmaceuticals, Inc.)
来源:	EP 0403713; EP 0409676; JP 1991038591; US 5693668

合成路线图解说明: The reaction of 1,3-dibromobenzene (I) with trimethylsilyl chloride (II) by means of Mg in ethyl ether gives 3-(trimethylsilyl)bromobenzene (III), which is then condensed with ethyl trifluoroacetate (IV) by means of butyllithium in ethyl ether - hexane.

参考文献No.	264192
标题:	Subreum
作者:	Prous, J.; Graul, A.; Casta馿r, J.
来源:	Drugs Fut 1994,19(9),845

合成路线图解说明: The reaction of 1,3-dibromobenzene (I) with trimethylsilyl chloride (II) by means of Mg in ethyl ether gives 3-(trimethylsilyl)bromobenzene (III), which is then condensed with ethyl trifluoroacetate (IV) by means of butyllithium in ethyl ether - hexane.