Vinxaltine sulfate, Vinfosiltine sulfate, Servier-12363, S-12363-药物合成数据库

【药物名称】Vinxaltine sulfate, Vinfosiltine sulfate, Servier-12363, S-12363

化学结构式(Chemical Structure):

参考文献No.	148128
标题:	Vinfosiltine Sulfate
作者:	Bizzari, J.P.
来源:	Drugs Fut 1991,16(9),822

合成路线图解说明: The condensation of O4-deacetyl-vinblastine carboxazide (I) with diethyl ester (+) of 1-amino-2-methylpropylphosphonic acid (II), in cold methylene chloride, gives (1S)-1-[3-(O4-deacetyl-3-demethoxycarbonylvincaleukoblastinyl) carbonylamino]-2-methylpropylphosphonic acid diethyl ester (III).

参考文献No.	164064
标题:	New alpha-aminophosphonic acid derivatives of vinblastine: Chemistry and antitumor activity
作者:	Lavielle, G.; Hautefaye, P.; Schaeffer, C.; Boutin, J.A.; Cudennec, C.A.; Pierr? A.
来源:	J Med Chem 1991,34(7),1998-2003

合成路线图解说明: The condensation of O4-deacetyl-vinblastine carboxazide (I) with diethyl ester (+) of 1-amino-2-methylpropylphosphonic acid (II), in cold methylene chloride, gives (1S)-1-[3-(O4-deacetyl-3-demethoxycarbonylvincaleukoblastinyl) carbonylamino]-2-methylpropylphosphonic acid diethyl ester (III).