Letrozole, FEM-345, CGS-20267, Femara-药物合成数据库

【药物名称】Letrozole, FEM-345, CGS-20267, Femara

化学结构式(Chemical Structure):

参考文献No.	7046
标题:	Alpha-heterocycle substd. Tolunitriles
作者:	Bowman, R.M.; Steele, R.E.; Browne, L.J. (Novartis AG)
来源:	EP 0236940; JP 1987212369

合成路线图解说明: Reaction of 4-bromomethylbenzonitrile (I) with 1,2,4-triazole (II) in chloroform - acetonitrile gives 1-(4-cyanophenyl)methyl-1,2,4-triazole (III), which is treated with potassium tert-butoxide and 4-fluorobenzonitrile (IV) in DMF.

参考文献No.	245953
标题:	Letrozole
作者:	Graul, A.; Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1994,19(4),335

合成路线图解说明: Reaction of 4-bromomethylbenzonitrile (I) with 1,2,4-triazole (II) in chloroform - acetonitrile gives 1-(4-cyanophenyl)methyl-1,2,4-triazole (III), which is treated with potassium tert-butoxide and 4-fluorobenzonitrile (IV) in DMF.