【药物名称】FG-5803
化学结构式(Chemical Structure):
参考文献No.1098
标题:Novel 1-piperazinecarboxamide derivs.
作者:Bjork, A.; Fex, T.; Olsson, K.; Abramo, A.; Gustafsson, B.; Christensson, E. (Ferrosan AB)
来源:EP 0136274; ES 8704917; ES 8705411; ES 8802039; JP 1985501956; US 4935419; WO 8500811
合成路线图解说明:

FG5803 is obtained in a three-step synthesis: In the first step 4-(4-fluorophenyl)-4,4-ethylenedioxybutylchloride (A) reacts with piperazine (B) to give 1-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]piperazine (I), which is reacted with cyclohexylisocyanate (C) to form 4-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]-N-cyclohexyl-1-piperazinecarboxamide (II). The protecting group is removed by HCl in ethanol and the final product is isolated, 4-[4-(4-fluorophenyl)-4-oxobutyl]-N-cyclohexyl-1-piperazinecarboxamide hydrochloride (III).

参考文献No.147155
标题:FG5803
作者:Lundstedt, T.; Bj鰎k, A.; Pettersson, G.; Svartengren, J.; Christensson, E.; Gustavsson, B.
来源:Drugs Fut 1990,15(12),1176
合成路线图解说明:

FG5803 is obtained in a three-step synthesis: In the first step 4-(4-fluorophenyl)-4,4-ethylenedioxybutylchloride (A) reacts with piperazine (B) to give 1-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]piperazine (I), which is reacted with cyclohexylisocyanate (C) to form 4-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]-N-cyclohexyl-1-piperazinecarboxamide (II). The protecting group is removed by HCl in ethanol and the final product is isolated, 4-[4-(4-fluorophenyl)-4-oxobutyl]-N-cyclohexyl-1-piperazinecarboxamide hydrochloride (III).

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