Mirfentanil hydrochloride, OHM-10579(free base), ANQ-3508 HCl, A-3508 hydrochloride-药物合成数据库

【药物名称】Mirfentanil hydrochloride, OHM-10579(free base), ANQ-3508 HCl, A-3508 hydrochloride

化学结构式(Chemical Structure):

参考文献No.	119984
标题:	New 4-(heteroanilido)-piperidines structurally related to the pure opioid agonist, fentanyl, with agonist and/or antagonist properties
作者:	Rudo, F.G.; Spender, H.K.; Doorley, B.M.; Wynn, R.L.; Spaulding, T.; Bagley, J.R.
来源:	J Med Chem 1989,32(3),663-671

合成路线图解说明: 4-Amino-1-phenethylpiperidine (I) is stirred with chloropyrazine (II) and copper powder in phenyl ether at 170-175 C to obtain 1-phenethyl-4-[N-(pyrazinyl)amino]piperidine (III). Subsequent acylation of (III) with 2-furoyl chloride in 1,2-dichloroethane yields mirfentanil as the hydrochloride salt after cooling and filtration. Further purification is achieved by recrystallization from n-propanol.

参考文献No.	140264
标题:	MIRFENTANIL HYDROCHLORIDE
作者:	Bagley, J.R.; Doorley, B.M.; Ossipov, M.H.; Knight, V.V.; Jerussi, T.P.; Benvenga, M.J.; Wilhelm, J.A.; Waters, S.J.; Spaulding, T.C.; Wynn, R.L.; Rudo, F.G.; Glass, P.S.A.
来源:	Drugs Fut 1990,15(8),798

合成路线图解说明: 4-Amino-1-phenethylpiperidine (I) is stirred with chloropyrazine (II) and copper powder in phenyl ether at 170-175 C to obtain 1-phenethyl-4-[N-(pyrazinyl)amino]piperidine (III). Subsequent acylation of (III) with 2-furoyl chloride in 1,2-dichloroethane yields mirfentanil as the hydrochloride salt after cooling and filtration. Further purification is achieved by recrystallization from n-propanol.