【药物名称】Nepinalone, Tussolvina(hydrochloride)
化学结构式(Chemical Structure):
参考文献No.13168
标题:Novel 1,2,3,4-tetrahydronaphthalen-2-ones and a process for the preparation thereof
作者:Fusco, R.; Tenconi, F. (Pfizer Inc.)
来源:GB 1140990; US 3576811
合成路线图解说明:

Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1). Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.

参考文献No.57801
标题:A process for the preparation of nepinalone
作者:Tenconi, F.; Furfaro, S.
来源:EP 0507001
合成路线图解说明:

Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1). Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.

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