【药物名称】Flufylline, Sgd-19578
化学结构式(Chemical Structure):
参考文献No.69988
标题:Flufylline
作者:Jahn, U.; Thiele, K.
来源:Drugs Fut 1984,9(8),579
合成路线图解说明:

The condensation of 7-(2-chloroethyl)theophylline (I) with 4-(p-fluorobenzoyl)piperidine (II) gives flufylline.

参考文献No.604473
标题:Neue biologisch aktive Theophyllin-Derivate
作者:Thiele, K.; Geissmann, F.; Jahn, U.; Zimgibl, L.
来源:Arzneim-Forsch Drug Res 1984,34(1),1
合成路线图解说明:

The condensation of 7-(3-chloropropyl)theophylline (I) with 4-(p-fluorobenzoyl)piperidine (II) gives fluprofylline.

合成路线图解说明:

The condensation of 7-(2-chloroethyl)theophylline (I) with 4-(p-fluorobenzoyl)piperidine (II) gives flufylline.

参考文献No.701198
标题:Theophylline derivatives
作者:Thiele, K.; Jahn, U.; Geissmann, F.; Zimgibl, L.
来源:ES 8304981; US 4603204; US 4668786; WO 8700841; ZA 8205123
合成路线图解说明:

The condensation of 7-(3-chloropropyl)theophylline (I) with 4-(p-fluorobenzoyl)piperidine (II) gives fluprofylline.

合成路线图解说明:

The condensation of 7-(2-chloroethyl)theophylline (I) with 4-(p-fluorobenzoyl)piperidine (II) gives flufylline.

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