【药物名称】Aprosulate sodium, LW-10082
化学结构式(Chemical Structure):
参考文献No.12323
标题:Polysulfuric ester of amides of bis-aldonic acids and their derivs., process for their preparation and medicine
作者:Meinetsberger, E. (Sankyo Pharma GmbH)
来源:EP 0312086; US 5008247
合成路线图解说明:

One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010, 1,3-diaminopropane (II) in dimethylformamide, SO3-pyridine complex and aqueous sodium hydroxide.

参考文献No.24224
标题:Bis-aldonic acid amide and process for their preparation
作者:Meinetsberger, E. (Sankyo Pharma GmbH)
来源:EP 0312087; US 5037973
合成路线图解说明:

One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010, 1,3-diaminopropane (II) in dimethylformamide, SO3-pyridine complex and aqueous sodium hydroxide.

参考文献No.260663
标题:Aprosulate Sodium
作者:Graul, A.; Casta馿r, J.; Prous, J.
来源:Drugs Fut 1994,19(8),721
合成路线图解说明:

One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010, 1,3-diaminopropane (II) in dimethylformamide, SO3-pyridine complex and aqueous sodium hydroxide.

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