【药物名称】Flutrimazole, UR-4056, Flusporan, Cutiman, Micetal
化学结构式(Chemical Structure):
参考文献No.181997
标题:Synthesis and antifungal activity of a series of difluorotritylimidazoles
作者:Forn, J.; Bartrol? J.; Alguer? M.; Boncompte, E.
来源:Arzneim-Forsch Drug Res 1992,42(6),832
合成路线图解说明:

A new synthesis for flutrimazole has been reported: The Grignard condensation of 2-fluorobenzophenone (I) with 4-fluorophenylmagnesium bromide (II) gives the corresponding triphenylcarbinol (III), which by reaction with refluxing SOCl2 is converted to the trityl chloride (IV). Finally, this compound is condensed with imidazole (V) in acetonitrile.

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