Midostaurin, PKC-412, CGP-41251-药物合成数据库

【药物名称】Midostaurin, PKC-412, CGP-41251

化学结构式(Chemical Structure):

参考文献No.	9544
标题:	Staurosporine derivs. substd. for the nitrogen atom of the methylamino group
作者:	Caravatti, G.; Fredenhagen, A. (Novartis AG)
来源:	EP 0296110; JP 1989034989; US 5093330

合成路线图解说明: The title benzamide was prepared by acylation of the alkaloid staurosporine (I) with benzoyl chloride (II) in the presence of diisopropylethylamine in chloroform.

参考文献No.	674380
标题:	Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C
作者:	Caravatti, G.; et al.
来源:	Bioorg Med Chem Lett 1994,4(3),399

合成路线图解说明: The title benzamide was prepared by acylation of the alkaloid staurosporine (I) with benzoyl chloride (II) in the presence of diisopropylethylamine in chloroform.