【药物名称】Latoconazole, Lanoconazole, TJN-318, NND-318, Astat
化学结构式(Chemical Structure):
参考文献No.11590
标题:Antimycotic agent and fungicidal agent
作者:Seo, A.; Kanno, H.; Hasegawa, N.; Miyagi, Y.; Nishimura, A.; Konaka, S.; Ohmi, T.; Munechika, Y.; Uchida, M.; Ikeda, K. (Nihon Nohyaku Co., Ltd.)
来源:US 4738976
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

参考文献No.11591
标题:Antifungal agent
作者:Seo, A.; Sugano, H.; Hasegawa, C.; Ikeda, K.; Munechica, Y.; Konoe, T.; Konaka, M. (Nihon Nohyaku Co., Ltd.)
来源:JP 1987093227
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

参考文献No.11592
标题:Non-medicinal bactericidal agents and method for their preparation
作者:Seo, A.; Sugano, H.; Hasegawa, C.; Ikeda, K.; Nishimura, A.; Miyashiro, Y. (Nihon Nohyaku Co., Ltd.)
来源:JP 1987093204
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

参考文献No.11593
标题:Ketene S,S-acetals
作者:Seo, A.; Sugano, H.; Hasegawa, C.; Miyashiro, Y.; Nishimura, A.; Ikeda, K. (Nihon Nohyaku Co., Ltd.)
来源:JP 1985218387
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

参考文献No.11594
标题:A novel ketene S,S-acetal deriv., a process for manufacturing thereof and a method for curing mycosis by administering it
作者:Seo, A.; Kanno, H.; Hasegawa, N.; Miyagi, Y.; Nishimura, A.; Konaka, S.; Ohmi, T.; Munechika, Y.; Uchida, M.; Ikeda, K. (Nihon Nohyaku Co., Ltd.)
来源:EP 0218736
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

参考文献No.203612
标题:Lanoconazole
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1993,18(3),222
合成路线图解说明:

The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II), which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III). A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.

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