【药物名称】Fepradinol, EL-508(HCl), Flexidol, Dalgen
化学结构式(Chemical Structure):
参考文献No.4265
标题:2-[N-(2-Hydroxy-1,1-dimethylethyl)amino]-1-phenylethanol which is useful, in particular, as an anti-inflammatory, and process for preparing it
作者:Montoro, F.; Calatayud, J.; Luna, M. (Byk Elmu SA)
来源:CH 670823; FR 2573071; JP 1986143344
合成路线图解说明:

Phenylglyoxylic acid (III) was converted to the corresponding acid chloride (IV) upon treatment with SOCl2. Subsequent coupling of (IV) with 2-amino-2-methyl-1-propanol (I) afforded amide (V). Reduction of the ketone and amide functions of (V) by means of LiAlH4 furnished the title compound.

参考文献No.57799
标题:Diethanolamine derivs.
作者:Staibano, G.; Fanelli, O. (Istituto Gentili SpA)
来源:GB 1336732
合成路线图解说明:

The title compound has been synthesized by two different methods. Condensation of 2-amino-2-methyl-1-propanol (I) with styrene oxide (II) provided the target amino diol.

参考文献No.58254
标题:Process for the preparation of ethyl-1-hydroxy-1-phenyl-2-(2-methyl-1-propanol)-amine, a new drug with antiinflammatory activity
作者:Montoro, F.; Calatayud, J.; Vila-Coro, A.; De la Fuente, R. (Byk Elmu SA)
来源:ES 453351
合成路线图解说明:

The title compound has been synthesized by two different methods. Condensation of 2-amino-2-methyl-1-propanol (I) with styrene oxide (II) provided the target amino diol.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us