【药物名称】Cilofungin, L-646991, LY-121019
化学结构式(Chemical Structure):
参考文献No.108140
标题:Echinocandin B. Ein Neuartiges Polypeptide-antibioticum aus Aspergillus nidulans var echinulatus: Isoleirung and Bausteine
作者:Benz, F.; Knusel, F.; Nuesch, J.; Trechler, H.; Voser, W.; Nefeler, R.; Keller-Schierlein, W.
来源:Helv Chim Acta 1974,572459
合成路线图解说明:

Cilofungin is a semi-synthetic anti-Candida agent that is derived from a three-step process: a) fermentation, isolation and purification of echinocandin B (ECB) (I) using an Aspergillus nidulans strain as the producing culture; b) deacylation of ECB by fermentation using an Actinoplanes utahensis culture to give the ECB nucleus (II); and c) N-acylation of the amino terminus of (II) using an activated ester of 4-octyloxybenzoic acid to give cilofungin.

参考文献No.108141
标题:Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin peptide: Synthesis of the antifungal agent cilofungin (LY-121019)
作者:Debono, M.; Abbott, B.J.; Fukuda, D.S.; Barnhart, M.; Willard, K.E.; Molloy, R.M.; Michel, K.H.; Turner, J.R.; Butler, T.F.; Hunt, A.H.
来源:J Antibiot 1989,42389
合成路线图解说明:

Cilofungin is a semi-synthetic anti-Candida agent that is derived from a three-step process: a) fermentation, isolation and purification of echinocandin B (ECB) (I) using an Aspergillus nidulans strain as the producing culture; b) deacylation of ECB by fermentation using an Actinoplanes utahensis culture to give the ECB nucleus (II); and c) N-acylation of the amino terminus of (II) using an activated ester of 4-octyloxybenzoic acid to give cilofungin.

参考文献No.108143
标题:Synthesis and evaluation of LY-121019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B
作者:Debono, M.; Abbott, B.J.; Turner, J.R.; Howard, L.C.; Gordee, R.S.; Hunt, A.H.; Barnhart, M.; Molloy, R.M.; Willard, K.E.; Fukuda, D.S.; Butler, T.F.; Zeckner, D.J.
来源:Ann NY Acad Sci 1988,152
合成路线图解说明:

Cilofungin is a semi-synthetic anti-Candida agent that is derived from a three-step process: a) fermentation, isolation and purification of echinocandin B (ECB) (I) using an Aspergillus nidulans strain as the producing culture; b) deacylation of ECB by fermentation using an Actinoplanes utahensis culture to give the ECB nucleus (II); and c) N-acylation of the amino terminus of (II) using an activated ester of 4-octyloxybenzoic acid to give cilofungin.

参考文献No.109637
标题:CILOFUNGIN < Prop INN; USAN >
作者:Gordee, R.; Debono, M.
来源:Drugs Fut 1989,14(10),939
合成路线图解说明:

Cilofungin is a semi-synthetic anti-Candida agent that is derived from a three-step process: a) fermentation, isolation and purification of echinocandin B (ECB) (I) using an Aspergillus nidulans strain as the producing culture; b) deacylation of ECB by fermentation using an Actinoplanes utahensis culture to give the ECB nucleus (II); and c) N-acylation of the amino terminus of (II) using an activated ester of 4-octyloxybenzoic acid to give cilofungin.

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