【药物名称】NSC-350386(hydrochloride hydrate), NSC-370147
化学结构式(Chemical Structure):
参考文献No.86592
标题:1,2-Dihydropyrido[3,4-b]pyrazines: Structure-activity relationships
作者:Temple, C. Jr.; et al.
来源:J Med Chem 1983,26(1),91
合成路线图解说明:

A number of 1-deaza-7,8-dihydropteridines with antimitotic activity have been prepared by the route shown in the scheme for NSC-350386 (1,2). Reaction of 2-aminopropiophenone oxime with ethyl 6-amino-4-chloro-5-nitropyridin-2-ylcarbamate (I) gave (II), which was hydrolyzed in a mixture of dioxane and hydrochloric acid to give the ketone (III). Reductive cyclization of (III) was effected with Raney Nickel and hydrogen.

参考文献No.607578
标题:New anticancer agents agents: Synthesis of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines)
作者:Temple, C. Jr.; Wheeler, G.P.; Elliot, R.D.; Rose, J.D.; Kussner, C.L.; Comber, R.N.; Montgomery, J.A.
来源:J Med Chem 1982,25(9),1045
合成路线图解说明:

A number of 1-deaza-7,8-dihydropteridines with antimitotic activity have been prepared by the route shown in the scheme for NSC-350386 (1,2). Reaction of 2-aminopropiophenone oxime with ethyl 6-amino-4-chloro-5-nitropyridin-2-ylcarbamate (I) gave (II), which was hydrolyzed in a mixture of dioxane and hydrochloric acid to give the ketone (III). Reductive cyclization of (III) was effected with Raney Nickel and hydrogen.

参考文献No.800390
标题:NSC-350386
作者:Wheeler, G.P.; Temple, C. Jr.
来源:Drugs Fut 1983,8(11),927
合成路线图解说明:

A number of 1-deaza-7,8-dihydropteridines with antimitotic activity have been prepared by the route shown in the scheme for NSC-350386 (1,2). Reaction of 2-aminopropiophenone oxime with ethyl 6-amino-4-chloro-5-nitropyridin-2-ylcarbamate (I) gave (II), which was hydrolyzed in a mixture of dioxane and hydrochloric acid to give the ketone (III). Reductive cyclization of (III) was effected with Raney Nickel and hydrogen.

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