Lazabemide hydrochloride, Ro-19-6327/001, Tempium, Pakio-药物合成数据库

【药物名称】Lazabemide hydrochloride, Ro-19-6327/001, Tempium, Pakio

化学结构式(Chemical Structure):

参考文献No.	3978
标题:	Ethylenediaminemonoamide derivs., pharmaceutical compsns. containing them and use of these cpds. As antidepressants or antiparkinsonians
作者:	Imhof, R.; Kyburz, E. (F. Hoffmann-La Roche AG)
来源:	AU 8546636; CH 661043; CH 664755; DE 3530046; ES 8705407; ES 8800158; FR 2569694; JP 1986060657; JP 1995300417; US 4764522

合成路线图解说明: The reaction of 5-chloropyridine-2-carboxylic acid (I) with N-(2-aminoethyl)carbamic acid tert-butyl ester (II) by means of carbonyl-dimidazole (CDI) in refluxing THF gives N-[2-(tert-butoxycarbonylamino)ethyl]-5-chloropyridine-2-carboxamide (III), which is then hydrolyzed with trifluoroacetic acid in refluxing dichloromethane and treated with ethanolic HCl to obtain the hydrochloride.

参考文献No.	198794
标题:	Lazabemide Hydrochloride
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1993,18(2),113

合成路线图解说明: The reaction of 5-chloropyridine-2-carboxylic acid (I) with N-(2-aminoethyl)carbamic acid tert-butyl ester (II) by means of carbonyl-dimidazole (CDI) in refluxing THF gives N-[2-(tert-butoxycarbonylamino)ethyl]-5-chloropyridine-2-carboxamide (III), which is then hydrolyzed with trifluoroacetic acid in refluxing dichloromethane and treated with ethanolic HCl to obtain the hydrochloride.