【药物名称】CI-949
化学结构式(Chemical Structure):
参考文献No.147006
标题:CI-949 AND RELATED INDOLECARBOXAMIDOTETRAZOLES: A NEW CLASS OF POTENTIAL ANTIALLERGY AGENTS
作者:Unangst, P.C.; Conroy, M.C.
来源:Drugs Fut 1990,15(10),1005
合成路线图解说明:

The alkylation of 3-hydroxy-5-methoxy-1-phenylindole-2-carboxylic acid methyl ester (I) with isopropyl bromide (II) and KOH gives the corresponding 2-isopropoxy compound (III), which is hydrolyzed with KOH and HOAc, yielding the carboxylic acid (IV). The condensation of (IV) with 1H-tetrazol-5-amine (V) by means of CDI affords the expected amide (VI), which is finally treated with L-arginine to furnish the target arginine salt.

参考文献No.803864
标题:Indole esters as heterocyclic synthons. III. Preparation and reactions of furo[3,2-b]indoles
作者:Unangst, P.C.; Carethers, M.E.
来源:J Heterocycl Chem 1984,21709-714
合成路线图解说明:

The alkylation of 3-hydroxy-5-methoxy-1-phenylindole-2-carboxylic acid methyl ester (I) with isopropyl bromide (II) and KOH gives the corresponding 2-isopropoxy compound (III), which is hydrolyzed with KOH and HOAc, yielding the carboxylic acid (IV). The condensation of (IV) with 1H-tetrazol-5-amine (V) by means of CDI affords the expected amide (VI), which is finally treated with L-arginine to furnish the target arginine salt.

参考文献No.803865
标题:Concerning N,N'-diphenyl-indigo
作者:Kunz, K.; Friendlander, P.
来源:Chem Ber 1922,551597-1607
合成路线图解说明:

The alkylation of 3-hydroxy-5-methoxy-1-phenylindole-2-carboxylic acid methyl ester (I) with isopropyl bromide (II) and KOH gives the corresponding 2-isopropoxy compound (III), which is hydrolyzed with KOH and HOAc, yielding the carboxylic acid (IV). The condensation of (IV) with 1H-tetrazol-5-amine (V) by means of CDI affords the expected amide (VI), which is finally treated with L-arginine to furnish the target arginine salt.

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