【药物名称】Sematilide hydrochloride, RU-752, ZK-110516, CK-1752A
化学结构式(Chemical Structure):
参考文献No.2911
标题:Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof.
作者:Lumma, W.C. Jr.; Davey, D.D.; Wohl, R.A. (Berlex Laboratories, Inc.)
来源:EP 0158775; JP 85209559; US 4544654
合成路线图解说明:

Reaction of p-aminobenzoic acid methyl ester (I) with methanesulfonyl chloride using pyridine as base provides the methanesulfonyl derivative (II). Heating (II) in heat N,N-diethyl-1,2-ethanediamine (III) at 140-50 C until complete disappearance of (II) gives the crude sematilide, which, after removal of excess diamine under vacuum, is crystallized as the hydrochloride salt from isopropanol/aqueous HCl.

参考文献No.85084
标题:SEMATILIDE HYDROCHLORIDE < Rec INNM; USAN >
作者:Lumma, W.C. Jr.
来源:Drugs Fut 1989,14(3),234
合成路线图解说明:

Reaction of p-aminobenzoic acid methyl ester (I) with methanesulfonyl chloride using pyridine as base provides the methanesulfonyl derivative (II). Heating (II) in heat N,N-diethyl-1,2-ethanediamine (III) at 140-50 C until complete disappearance of (II) gives the crude sematilide, which, after removal of excess diamine under vacuum, is crystallized as the hydrochloride salt from isopropanol/aqueous HCl.

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