【药物名称】IDPH-791
化学结构式(Chemical Structure):
参考文献No.79255
标题:IDPH-791
作者:Arya, V.P.
来源:Drugs Fut 1989,14(2),125
合成路线图解说明:

Title compound can be prepared by two different ways: 1) Reaction of 2H-[1,4]benzothiazin-3(4H)-one (I) with POCl3 in the presence of triethylamine followed by treatment with ethyl carbazate gives 3-carbethoxyhydrazinyl[1,4]benzothiazine (II), which is thermally cyclized by refluxing in o-dichlorobenzene (ODCB) to give 1-oxo-2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-one. 2) Alternatively, IDPH-791 can be prepared by converting 2H-[1,4]benzothiazin-3(4H)-one (I) to the thione (III), followed by reaction with ethyl carbazate in refluxing DMF.

参考文献No.803921
标题:
作者:Narayan, G.K.A.S.S.; Shridhar, D.R.; Vishwakarma, L.C.; Reddy Sastry, C.V.
来源:Org Prep Proced Int 1980,12203
合成路线图解说明:

Title compound can be prepared by two different ways: 1) Reaction of 2H-[1,4]benzothiazin-3(4H)-one (I) with POCl3 in the presence of triethylamine followed by treatment with ethyl carbazate gives 3-carbethoxyhydrazinyl[1,4]benzothiazine (II), which is thermally cyclized by refluxing in o-dichlorobenzene (ODCB) to give 1-oxo-2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-one. 2) Alternatively, IDPH-791 can be prepared by converting 2H-[1,4]benzothiazin-3(4H)-one (I) to the thione (III), followed by reaction with ethyl carbazate in refluxing DMF.

参考文献No.900156
标题:Synthesis of new tricyclic triazoles of pharmacological interest.
作者:Shridhar, D.R.; Jogibhukta, M.; Joshi, P.P.; Narayan, G.K.A. (Indian Drugs & Pharm.)
来源:IN 15368
合成路线图解说明:

Title compound can be prepared by two different ways: 1) Reaction of 2H-[1,4]benzothiazin-3(4H)-one (I) with POCl3 in the presence of triethylamine followed by treatment with ethyl carbazate gives 3-carbethoxyhydrazinyl[1,4]benzothiazine (II), which is thermally cyclized by refluxing in o-dichlorobenzene (ODCB) to give 1-oxo-2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-one. 2) Alternatively, IDPH-791 can be prepared by converting 2H-[1,4]benzothiazin-3(4H)-one (I) to the thione (III), followed by reaction with ethyl carbazate in refluxing DMF.

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