【药物名称】Tilnoprofen arbamel, Y-23023
化学结构式(Chemical Structure):
参考文献No.9004
标题:Benzopyranopyridine acid ester cpds. and their pharmaceutical uses
作者:Oe, T.; Kawasaki, K.; Terasawa, M.; Imayoshi, T. (Japan Tobacco Inc.; Welfide Corporation)
来源:EP 0284069; JP 1989025782; US 4808593
合成路线图解说明:

By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.

参考文献No.106892
标题:Synthesis, pharmacological activity and biopharmaceutical characteristics of alpha,2-dimethyl-5H-[1]benzopyrano[2,3-d]pyridine-7-acetates
作者:Kawasaki, K.; Yamada, I.; Oe, T.; Tsuruda, M.; Terasawa, M.; Imayoshi, T.; Yasunaga, Y.; Goto, K.
来源:Yakugaku Zasshi 1989,109(11),827
合成路线图解说明:

By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.

参考文献No.175509
标题:Y-23023
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1992,17(6),469
合成路线图解说明:

By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.

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