【药物名称】Meldonium hydrate, Quaterin, Mildronate, MET-88, Q-4224-IOS, THP(anhydrous)
化学结构式(Chemical Structure):
参考文献No.9107
标题:3-(2,2,2-Trimethylhydrazinium)propionate, method of obtaining it and use
作者:Guiller, S.A.; Eremeev, A.V.; Kalvinsh, I.Y.; Semenikhina, V.G.; Liepinsh, E.A.; Latvietis, Y.Y.; Anderson, P.P.; Astapenok, E.B.; Spruzh, Y.Y.; Trapetsiers, P.T.; Podoprigora, G.I. (Latvian Institute of Organic Synthesis)
来源:WO 8001068
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

参考文献No.9109
标题:3-(2,2,2-Trimethylhydrazinium)propionate, process for their preparation and use
作者:Eremeev, A.V.; Kalvinsh, V.G.; Semenikhina, V.G.; Liepinsh, E.E.; Latvietis, Y.Y.; Anderson, P.P.; Astapenok, F.B.; Spuzh, Y.Y.; Trapentsiers, G.T.; Podoprigora, G.I.; Giller, S.A. (Latvian Institute of Organic Synthesis)
来源:FR 2478087
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

参考文献No.76485
标题:MILDRONATE
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(1),29
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

参考文献No.98353
标题:Molecular-crystalline structure of 3-(2,2, 2-trimethylhydrazinio)propionate dihydrate C6H14N2O2.2H2O
作者:Kemme, A.; Bleidelis, J.; Kalvins, I.; Eremeev, A.V.
来源:Latv Psr Zinat Akad Vestis 1983,2215-8
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

参考文献No.803919
标题:
作者:Bremanis, G.; Shimanskaya, M.V.; Lukevicz, E.Ya.; Kalvinsh, I.Ya.; Goldberg, Yu. Sh.; Abele, E.
来源:Dokl Akad Nauk SSSR (Khim) 1987,2941387
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

参考文献No.900151
标题:Treatment of cardiovascular diseases with 3-(2,2,2-trimethylhydrazinium) propionate dihydrate.
作者:Kalvinsh, I.Y.; Vinogradov, A.V.; Veveris, M.M.; Makarova, I.I.; Birman, A.S.; Barmotin, G.V.; Akifiev, O.N. (Institu Orch Sinteza Akademii)
来源:DE 3234537; GB 2105992; JP 58074606; US 4451485
合成路线图解说明:

Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II, X = halo) or dimethyl sulfate (II, X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III), which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form). After crystallization from ethanol the inner salt is obtained as a dihydrate.

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