Technetium (99mTc) bicisate, Technetium Tc99m bicisate, RP-217(diHCl), ECD-[99mTc], [99mTc]-ECD, Neurolite-药物合成数据库

【药物名称】Technetium (99mTc) bicisate, Technetium Tc99m bicisate, RP-217(diHCl), ECD-[99mTc], [99mTc]-ECD, Neurolite

化学结构式(Chemical Structure):

参考文献No.	8855
标题:	Ester-substd. diaminedithiols and radiolabeled complexes thereof
作者:	Bergstein, P.L.; Cheesman, E.H.; Watson, A.D. (DuPont Pharmaceuticals Co.)
来源:	AU 8811748; EP 0279417; JP 1988285549

合成路线图解说明: The reductive dimerization of thiazolidine-4(R)-carboxylic acid sodium salt (I) with Na in liquid ammonia gives N,N-ethylene-1,2-diylbis(cysteine) (II), which is esterified with ethanol and dry HCl to the corresponding diethyl ester (III). Finally, this compound is treated with sodium pertechnetate and a reducing agent such as stannous salts, NaBH4 or Na2S2O4.

参考文献No.	288017
标题:	Technetium (Tc99m) Bicisate
作者:	Casta馿r, J.; Robinson, C.
来源:	Drugs Fut 1995,20(3),251

合成路线图解说明: The reductive dimerization of thiazolidine-4(R)-carboxylic acid sodium salt (I) with Na in liquid ammonia gives N,N-ethylene-1,2-diylbis(cysteine) (II), which is esterified with ethanol and dry HCl to the corresponding diethyl ester (III). Finally, this compound is treated with sodium pertechnetate and a reducing agent such as stannous salts, NaBH4 or Na2S2O4.