【药物名称】Nicorandil, RP-46417, SG-75, Adancor, Ikorel, Dancor, Sigmart
化学结构式(Chemical Structure):
参考文献No.65911
标题:SG-75
作者:Thorpe, P.J.; Casta馿r, J.
来源:Drugs Fut 1979,4(2),134
合成路线图解说明:

The esteritication of nicotinic acid (I) with methanol and HCl or H2SO4 yields the corresponding methyl ester (II), which is treated with ethanolamine (A) to afford N-(beta-hydroxyethyl)nicotinamide (III). Finally, this compound is transformed into the nitrate ester by the usual methods.

参考文献No.800241
标题:Solubilizing agents. V. Pyridinecarboxamides
作者:Masayoshi, S.
来源:Yakugaku Zasshi 1960,801706-12
合成路线图解说明:

The esteritication of nicotinic acid (I) with methanol and HCl or H2SO4 yields the corresponding methyl ester (II), which is treated with ethanolamine (A) to afford N-(beta-hydroxyethyl)nicotinamide (III). Finally, this compound is transformed into the nitrate ester by the usual methods.

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