【药物名称】EM-523
化学结构式(Chemical Structure):
参考文献No.6010
标题:Erythromycin derivs. and process for preparing the same
作者:Omura, S.; Itoh, Z. (Kitasato Institute)
来源:AU 8661583; EP 0215355; JP 1988099092; US 5175150
合成路线图解说明:

By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.

参考文献No.130136
标题:Safety and pharmacokinetics of recombinant CD4 in children with HIV infection
作者:Weintrub, P.; et al.
来源:Int Conf AIDS 1990,Abst F.B.23
合成路线图解说明:

By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.

参考文献No.168163
标题:Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-Substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal
作者:Tsuzuki, K.; Toyoda, H.; Inatomi, N.; Sunazuka, T.; Omura, S.; Marui, S.; Itoh, Z.
来源:Chem Pharm Bull 1989,37(10),2687
合成路线图解说明:

By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.

合成路线图解说明:

Title compound was obtained by cyclization of N-demethyl-N-acetyl erythromycin A (I) in glacial AcOH at room temperature.

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