【药物名称】M-17055
化学结构式(Chemical Structure):
参考文献No.7252
标题:1-Acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivs.
作者:Uemura, A.; Mochida, E.; Haga, A.; Tokunaga, H.; Kato, K. (Mochida Pharmaceutical Co., Ltd.)
来源:AU 9058618; EP 0243982; JP 1988239270; JP 1993262737; US 4739368; WO 8706580
合成路线图解说明:

The condensation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one (I) with 2-methylbenzoyl chloride (II) by means of pyridine in dichloromethane gives the corresponding acyl quinolone (III), which is then treated with hydroxylamine-O-sulfonic acid (IV) and K2CO3 to yield the target oxime.

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