【药物名称】Sepimostat mesilate, TO-187, FUT-187
化学结构式(Chemical Structure):
参考文献No.3958
标题:Novel amidine cpds
作者:Fujii, S.; Okutome, T.; Nakayama, T.; Nunomura, S.; Sudo, K.; Watanabe, S.; Kurumi, M.; Aoyama, T. (Torii Pharmaceutical Co., Ltd.)
来源:AU 8545492; EP 0190356; ES 8607218; US 4777182; US 4820730; WO 8600893
合成路线图解说明:

Esterification of 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoic acid methanesulfonate (I) with 6-amidino-2-naphthol methanesulfonate (II) by means of dimethylaminopyridine (DMAP) and dicyclohexylcarbodiimide (DCC) in dry pyridine.

参考文献No.202874
标题:Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate
作者:Nakayama, T.; Taira, S.; Ikeda, M.; Ashizawa, H.; Oda, M.; Arakawa, K.; Fujii, S.
来源:Chem Pharm Bull 1993,41(1),117-25
合成路线图解说明:

Esterification of 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoic acid methanesulfonate (I) with 6-amidino-2-naphthol methanesulfonate (II) by means of dimethylaminopyridine (DMAP) and dicyclohexylcarbodiimide (DCC) in dry pyridine.

参考文献No.408602
标题:Sepimostat Mesylate
作者:Graul, A.; Leeson, P.; Casta馿r, J.
来源:Drugs Fut 1997,22(5),502
合成路线图解说明:

Esterification of 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoic acid methanesulfonate (I) with 6-amidino-2-naphthol methanesulfonate (II) by means of dimethylaminopyridine (DMAP) and dicyclohexylcarbodiimide (DCC) in dry pyridine.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us