Emitefur, BOF-A2, Last-F-药物合成数据库

【药物名称】Emitefur, BOF-A2, Last-F

化学结构式(Chemical Structure):

参考文献No.	7711
标题:	5-Fluorouracil derivs., process for their preparation and their use
作者:	Fujii, S. (Otsuka Pharmaceutical Co., Ltd.)
来源:	DE 3709699; FR 2605006; GB 2192880; JP 1988201127; JP 1988301880

合成路线图解说明: By condensation of 3-[3-(chlorocarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil (I) with 6-benzoyloxy-3-cyano-2-hydroxypyridine (II) by means of triethylamine in refluxing acetonitrile. The starting compounds (I) and (II) are obtained as follows: The reaction of 1-(ethoxymethyl)-5-fluorouracil (III) with isophthaloyl dichloride (IV) by means of triethylamine in refluxing dioxane gives uracil (I). The esterification of 3-cyano-2,6-dihydroxypyridine (V) with benzoyl chloride (VI) by means of triethylamine in dimethylacetamide affords pyridine (II).

参考文献No.	204972
标题:	Emitefur
作者:	Casta馿r, J.; Hoshi, A.
来源:	Drugs Fut 1993,18(5),418

合成路线图解说明: By condensation of 3-[3-(chlorocarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil (I) with 6-benzoyloxy-3-cyano-2-hydroxypyridine (II) by means of triethylamine in refluxing acetonitrile. The starting compounds (I) and (II) are obtained as follows: The reaction of 1-(ethoxymethyl)-5-fluorouracil (III) with isophthaloyl dichloride (IV) by means of triethylamine in refluxing dioxane gives uracil (I). The esterification of 3-cyano-2,6-dihydroxypyridine (V) with benzoyl chloride (VI) by means of triethylamine in dimethylacetamide affords pyridine (II).