Prinoxodan, RGW-2938, WHR-2938-药物合成数据库

【药物名称】Prinoxodan, RGW-2938, WHR-2938

化学结构式(Chemical Structure):

参考文献No.	6451
标题:	Benzodiazinone-pyridazinone and hydroxy-pyrazolyl cpds., cardiotonic compsns. including the same, and their uses
作者:	Kuhla, D.E.; Campbell, H.F.; Studt, W.L.; Faith, W.C.; Molino, B.F. (Aventis Pharma SA)
来源:	EP 0247177; JP 1988502030; US 4725686; WO 8703201

合成路线图解说明: The cyclization of 2-(methylaminomethyl)aniline (I) with 1,1'-carbonyldiimidazole (II) in refluxing THF gives 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (III), which is condensed with methyl succinyl chloride (IV) by means of anhydrous AlCl3 in refluxing carbon disulfide to yield 6-[3-(methoxycarbonyl)propionyl]-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (V). Finally, this compound is cyclocondensed with hydrazine in refluxing ethanol.

参考文献No.	79251
标题:	RGW-2938
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(2),132

合成路线图解说明: The cyclization of 2-(methylaminomethyl)aniline (I) with 1,1'-carbonyldiimidazole (II) in refluxing THF gives 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (III), which is condensed with methyl succinyl chloride (IV) by means of anhydrous AlCl3 in refluxing carbon disulfide to yield 6-[3-(methoxycarbonyl)propionyl]-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (V). Finally, this compound is cyclocondensed with hydrazine in refluxing ethanol.