【药物名称】Epinastine hydrochloride, WAL-801CL, Elestat, Relestat, Flurinol, Alesion
化学结构式(Chemical Structure):
参考文献No.118102
标题:New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine
作者:Walther, G.; Bechtel, W.D.; Daniel, H.; Brandt, K.
来源:Arzneim-Forsch Drug Res 1990,40(4),440-6
合成路线图解说明:

A new synthesis of epinastine hydrochloride has been described: The reaction of 6-chloro-11H-dibenzo[b,e]azepine (I) with NaCN in DMSO at 90 C gives 11H-dibenzo[b,e]azepine-6-carbonitrile (II), which is reduced with AlH3 (prepared from LiAlH4 and H2SO4 in THF) in THF to afford 6-(aminomethyl)-6,11-dihydro-5H-dibenzo[b,e]azepine (III). Finally, this compound is cyclized with cyanogen bromide in THF and treated with HCl.

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