BY-1947-药物合成数据库

【药物名称】BY-1947

化学结构式(Chemical Structure):

参考文献No.	41523
标题:	Dibenzoxazepine derivative, and pharmaceutical composition comprising the same
作者:	Sasahara, K.; Muramaki, Y.; Neichi, T.; Koizumi, M.; Matsushita, H.; Hata, S.; Honda, M.; Nakakimura, H.; Noda, Y. (Chugai Pharmaceutical Co. Ltd.)
来源:	EP 0040860; JP 1981166180; US 4435391

合成路线图解说明: The cyclization of ethyl 3-propionylamino-4-(3-methoxyphenoxy)benzoate (I) by means ot POCl3 in refluxing toluene gives ethyl 11-ethyl-3-methoxydibenz[b,f][1,4]oxazepine-8-carboxylate (II), which is then hydrolyzed with NaOH in refluxing methanol water.

参考文献No.	561385
标题:	BY-1947
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1984,9(3),173

合成路线图解说明: The cyclization of ethyl 3-propionylamino-4-(3-methoxyphenoxy)benzoate (I) by means ot POCl3 in refluxing toluene gives ethyl 11-ethyl-3-methoxydibenz[b,f][1,4]oxazepine-8-carboxylate (II), which is then hydrolyzed with NaOH in refluxing methanol water.