Mivacurium chloride, BW-B1090U, Mivacron-药物合成数据库

【药物名称】Mivacurium chloride, BW-B1090U, Mivacron

化学结构式(Chemical Structure):

参考文献No.	4585
标题:	Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts, their preparation and pharmaceutical compsns. containing them
作者:	Swaringen, R.A. Jr.; El-Sayad, H.A.; Yeowell, D.A.; Savarese, J.J. (General Hospital Corporation; GlaxoSmithKline plc)
来源:	EP 0181055; ES 8609260; JP 1986087666; JP 1986087666; US 4761419

合成路线图解说明: The optical resolution of (?-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I), which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III). Finally, this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.

参考文献No.	96000
标题:	MIVACURIUM CHLORIDE < Rec INN; BAN >
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(7),632

合成路线图解说明: The optical resolution of (?-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I), which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III). Finally, this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.