Quinupristin mesilate, RP-57669-药物合成数据库

【药物名称】Quinupristin mesilate, RP-57669

化学结构式(Chemical Structure):

参考文献No.	23706
标题:	Pristinaymcin IA or viginiamycin derivs. and their preparation
作者:	Bastart, J.P.; Paris, J.M.; Radisson, X. (Aventis SA)
来源:	EP 0432029

合成路线图解说明: The condensation of the cyclopeptide analogue (I) with morpholine (II) and formaldehyde by means of MsOH in hot methanol gives the 4-morpholinylmethyl derivative (III), which by a treatment with NaOAc in hot acetic acid yields the methylene derivative (IV). Finally this compound is condensed with quinuclidine-3(S)-thiol in hot acetone.

参考文献No.	228688
标题:	RP 59500 and related semisynthetic streptogramins
作者:	Barri鑢e, J.C.; Paris, J.M.
来源:	Drugs Fut 1993,18(9),833

合成路线图解说明: The condensation of the cyclopeptide analogue (I) with morpholine (II) and formaldehyde by means of MsOH in hot methanol gives the 4-morpholinylmethyl derivative (III), which by a treatment with NaOAc in hot acetic acid yields the methylene derivative (IV). Finally this compound is condensed with quinuclidine-3(S)-thiol in hot acetone.