【药物名称】Tazifylline hydrochloride, RS-49014
化学结构式(Chemical Structure):
参考文献No.139
标题:Piperazine derivatives of theophylline
作者:Favier, C.; Pinhas, H.; Beranger, S.; Pascal, J.-C. (Roche Bioscience)
来源:EP 0033674; GB 2069487; JP 56120683; US 4374835
合成路线图解说明:

The reaction of 1-bromo-3-chloropropane (I) with thiophenol (II) by means of NaOH in refluxing water gives 1-(phenylthio)-3-chloropropane (III), which is condensed with piperazine (IV) by means of NaOH in refluxing ethanol-water yielding 1-(3-phenylthiopropyl)piperazine (V). Finally, this compound is condensed with 7-(2,3-epoxypropyl)theophylline (VI) in refluxing ethanol.

参考文献No.79480
标题:Tazifylline Hydrochloride
作者:Casta馿r, R.M.; Casta馿r, J.; Serradell, M.N.; Tester-Dalderup, C.
来源:Drugs Fut 1987,12(11),1036
合成路线图解说明:

The reaction of 1-bromo-3-chloropropane (I) with thiophenol (II) by means of NaOH in refluxing water gives 1-(phenylthio)-3-chloropropane (III), which is condensed with piperazine (IV) by means of NaOH in refluxing ethanol-water yielding 1-(3-phenylthiopropyl)piperazine (V). Finally, this compound is condensed with 7-(2,3-epoxypropyl)theophylline (VI) in refluxing ethanol.

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