【药物名称】Azetirelin dihydrate, YM-14673
化学结构式(Chemical Structure):
参考文献No.600
标题:4-Substituted-2-azetidinone compounds, process for producing them and medicaments containing them
作者:Iwamoto, H.; Yoshida, M.; Yamamoto, M.; Tamura, T. (Yamanouchi Pharmaceutical Co., Ltd.)
来源:AU 8426100; EP 0123444; ES 86279; ES 864209; JP 84225182; JP 85115577; JP 85115578; US 4564609; US 4636567; US 610821
合成路线图解说明:

By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.

参考文献No.601
标题:Novel crystals of Nalpha-[[(S)-4-oxo-2-azetidinyl]carbenyl]-L-histidyl-L-prolinamide and process for producing the crystals
作者:Tamura, T.; Matsuda, H.; Yoshida, M. (Yamanouchi Pharmaceutical Co., Ltd.)
来源:AU 8666308; EP 0225796; JP 87234094
合成路线图解说明:

By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.

参考文献No.76477
标题:AZETIRELIN DIHYDRATE < Prop INNM >
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(3),203
合成路线图解说明:

By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.

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