Doxacurium chloride, BW-A938U, Nuromax-药物合成数据库

【药物名称】Doxacurium chloride, BW-A938U, Nuromax

化学结构式(Chemical Structure):

参考文献No.	8643
标题:	Long duration neuromuscular blocking agents, pharmaceutical compsns. containing them and processes for their preparation
作者:	El-Sayad, H.A.; Yeowell, D.A.; Swaringen, R.A. Jr. (GlaxoSmithKline plc)
来源:	EP 0054309; US 4701460

合成路线图解说明: 5',8-Dimethoxylaudanosine (I) is condensed with 3-iodopropanol (II) in refluxing acetone and passed through Dowex 1-X8 ion exchange resin to give trans-N-(3-hydroxypropyl)-5',8-dimethoxylaudanosinium chloride (III), which is then esterified with succinyl chloride (IV) in refluxing dichloroethane.

参考文献No.	76476
标题:	DOXACURIUM CHLORIDE < Rec INN; BAN >
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(3),211

合成路线图解说明: 5',8-Dimethoxylaudanosine (I) is condensed with 3-iodopropanol (II) in refluxing acetone and passed through Dowex 1-X8 ion exchange resin to give trans-N-(3-hydroxypropyl)-5',8-dimethoxylaudanosinium chloride (III), which is then esterified with succinyl chloride (IV) in refluxing dichloroethane.