【药物名称】Fotemustine, S-10036, Servier-10036, Muphoran
化学结构式(Chemical Structure):
参考文献No.8638
标题:New nitrosourea derivs., process for preparing them and pharmaceutical compsns. containing them
作者:Lavielle, G.; Cudennec, C. (ADIR et Cie.)
来源:FR 2536075
合成路线图解说明:

The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III), which is then treated with sodium nitrite and formic acid.

参考文献No.109641
标题:FOTEMUSTINE < Rec INN >
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(11),1042
合成路线图解说明:

The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III), which is then treated with sodium nitrite and formic acid.

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