【药物名称】L-Dopa ethyl ester, Etilevodopa, Levodopa ethyl ester, TV-1203
化学结构式(Chemical Structure):
参考文献No.47799
标题:Process for preparing ethyl ester of L-DOPA
作者:Atlas, D.; Veinberg, A.; Melamed, E.; Milman, I. (Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.)
来源:EP 0610595; US 5354885
合成路线图解说明:

Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.

参考文献No.47801
标题:Process for manufacture of L-DOPA ethyl ester
作者:Bahar, E.; Lidor, R.; Frenkel, A. (Teva Pharmaceutical Industries Ltd.; Teva Pharmaceuticals USA, Inc.)
来源:US 6218566; WO 0027801
合成路线图解说明:

Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.

参考文献No.608787
标题:Facile synthesis of L-Dopa esters by the combined use of tyrosinase and alpha-chymotrypsin
作者:Ahmed, G.; Vulfson, E.N.
来源:Biotechnol Lett 1994,16(4),367
合成路线图解说明:

Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.

参考文献No.615455
标题:Etilevodopa
作者:Sorbera, L.A.; Leeson, P.; Casta馿r, J.; Mart韓, L.
来源:Drugs Fut 2001,26(3),219
合成路线图解说明:

Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.

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