【药物名称】Piroxicam pivalate, CHF-10/21, Unicam
化学结构式(Chemical Structure):
参考文献No.8627
标题:Benzo-1,2-thiazine 1,1-dioxide derivs., their preparation and their use
作者:Chiesi, P.; Villani, F. (Chiesi Farmaceutici SpA)
来源:BE 0895712; EP 0085866
合成路线图解说明:

Saccharin (II) was obtained by acidification of a solution of sodium 2-sulfamoylbenzoate (I). Alkylation of the sulfimide N of (II) with N-(2-pyridyl)bromoacetamide (III) under phase-transfer conditions afforded (IV). Rearrangement of sulfimide (IV) in the presence of sodium methoxide gave rise to the benzothiazine derivative (V). From this, the title compound was prepared by two related ways. Esterification of (V) with trimethylacetyl chloride yielded pivalate ester (VI), which was subsequently alkylated at the sulfamide N with iodomethane in the presence of NaOH. Alternatively, methylation of (V), followed by esterification of the resultant (VII) with pivaloyl chloride led to the title compound.

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