【药物名称】Elliprabin, Ellipravin, SUN-4599
化学结构式(Chemical Structure):
参考文献No.4018
标题:Ellipticine derivs.
作者:Honda, T.; Nakanishi, T. (Suntory Ltd.)
来源:AU 8545252; EP 0173462; JP 1986037799; JP 1987022794; JP 1987022795; JP 1987030795; US 4698423
合成路线图解说明:

The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III), which is then deprotected by treatment with dry ammonia in methanol.

参考文献No.79249
标题:ELLIPRAVIN
作者:Hoshi, A.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(2),116
合成路线图解说明:

The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III), which is then deprotected by treatment with dry ammonia in methanol.

参考文献No.92816
标题:Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents
作者:Honda, T.; Kato, M.; Inoue, M.; Shimamoto, T.; Shima, K.; Nakanishi, T.; Yoshida, T.; Noguchi, T.
来源:J Med Chem 1988,31(7),1295-305
合成路线图解说明:

The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III), which is then deprotected by treatment with dry ammonia in methanol.

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