The reaction of 3 p-tolylthiophene (I) with N-bromosuccinimide in refluxing CCl4 in the presence of azobisisobutyronitrile or benzoyl peroxide as catalyst gives 4-(3-thienyl)benzyl bromide (II), which is converted to 4-(3-thienyl)phenylacetonitrile (III) by treatment with NaCN in refluxing dichloroethane using tetrabutyl ammonium hydrogen sulfate as catalyst Methylation of nitrile (III) with methyl iodide dimethylcarbonate in the presence of sodium methoxide, followed by acid hydrolysis of the resulting 4-(3-thienyl)phenyl-alpha-methylacetonitrile (IV) by refluxing with acetic acid hydrochloric acid (V), gives 4 (3-thienyl)phenyl-alpha-methylacetic acid (V), which is finally esterified by refluxing with CH3OH - H2SO4 to give IDPH-8261.

The reaction of 3 p-tolylthiophene (I) with N-bromosuccinimide in refluxing CCl4 in the presence of azobisisobutyronitrile or benzoyl peroxide as catalyst gives 4-(3-thienyl)benzyl bromide (II), which is converted to 4-(3-thienyl)phenylacetonitrile (III) by treatment with NaCN in refluxing dichloroethane using tetrabutyl ammonium hydrogen sulfate as catalyst Methylation of nitrile (III) with methyl iodide dimethylcarbonate in the presence of sodium methoxide, followed by acid hydrolysis of the resulting 4-(3-thienyl)phenyl-alpha-methylacetonitrile (IV) by refluxing with acetic acid hydrochloric acid (V), gives 4 (3-thienyl)phenyl-alpha-methylacetic acid (V), which is finally esterified by refluxing with CH3OH - H2SO4 to give IDPH-8261.