Lacidipine, SN-305, GX-1048, GR-43659X, Viapres, Caldine, Motens, Lacipil, Lacirex-药物合成数据库

【药物名称】Lacidipine, SN-305, GX-1048, GR-43659X, Viapres, Caldine, Motens, Lacipil, Lacirex

化学结构式(Chemical Structure):

参考文献No.	80598
标题:	LACIDIPINE < Rec INN; BAN; USAN >
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(4),317

合成路线图解说明: The Wittig condensation of o-phthalaldehyde (I) with tert-butyl triphenylphosphoranylideneacetate (II) in methylene chloride gives tert-butyl 3-(2-formylphenyl)-2(E)-propenoate (III), which is then cyclized with ethyl 3-aminocrotonate (IV) in acetic acid.

参考文献No.	900157
标题:	1,4-dihydropyridines.
作者:	Borthwick, A.D.; Pierccioli, D.; Micheli, D.; Semeraro, C.; Gaviraghi, G. (Glaxo SpA)
来源:	ES 8703839; ES 8703839; US 4801599; US 5011848

合成路线图解说明: The Wittig condensation of o-phthalaldehyde (I) with tert-butyl triphenylphosphoranylideneacetate (II) in methylene chloride gives tert-butyl 3-(2-formylphenyl)-2(E)-propenoate (III), which is then cyclized with ethyl 3-aminocrotonate (IV) in acetic acid.