【药物名称】SH-D515, ZK-91587
化学结构式(Chemical Structure):
参考文献No.110160
标题:Aldosterone antagonists. 3. Synthesis and activities of steroidal 7alpha -(alkoxycarbonyl)-15,16-methylene spirolactones
作者:Nishino, Y.; Wiechert, R.; Laurent, H.; Bittler, D.; Losert, W.; Nickisch, K.; Schillinger, E.
来源:J Med Chem 1990,33(2),509-13
合成路线图解说明:

The synthesis of ZK-91587 has been described: The reaction of 15beta,16beta-methylene-3-oxo-17alpha-pregna-4,6-diene-21,17-carbonolactone (I) with diethylaluminum cyanide in THF or with KCN and NH4Cl in DMF - water gives 7alpha-cyano-15beta,16beta-methylene-3-oxo-17alpha-pregn-21,17-carbonolactone (II), which by partial reduction with diisobutylaluminum hydride in toluene is converted into the corresponding aldehyde (III). The oxidation of (III) with Jones' reagent (CrO3) affords the carboxylic acid (IV), which is finally methylated with diazomethane in dichloromethane.

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